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It belongs to a group of medications called statins. Changes to diet and exercise are often combined with this medication. Introduction Rosuvastatin (Crestor) is a prescription medication used to treat high cholesterol and prevent heart attacks and strokes. It belongs to a class of drugs called statins, which lower cholesterol by inhibiting the HMG-CoA reductase enzyme and increasing cholesterol breakdown in the liver. Rosuvastatin is available in tablet form. ROSUVASTATIN (roe SOO va sta tin) treats high cholesterol and reduces the risk of heart attack and stroke. It works by decreasing bad cholesterol and fats (such as LDL, triglycerides) and increasing good cholesterol (HDL) in your blood. It belongs to a group of medications called statins. Changes to diet and exercise are often combined with this medication. Rosuvastatin Calcium or Crestor Savings, Coupons and Information. | ROSUVASTATIN (roe SOO va sta tin) treats high cholesterol and reduces the risk of heart attack and stroke. 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