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Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Pristiq is an antidepressant used off-label for treating anxiety and panic disorders, but it is FDA-approved only for major depressive disorder. Common side effects of Pristiq include dizziness, nausea, insomnia, and sexual dysfunction, which often improve within a couple of weeks. Pristiq carries a risk of increased suicidal thoughts in young people, requiring close monitoring. Medscape – Major depressive disorder dosing for Pristiq (desvenlafaxine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Generic name: desvenlafaxine (des ven la FAX een) Tablets (extended release): 25 mg, 50 mg, 100 mg Brand name: Pristiq® Tablets (extended release): 25 mg, 50 mg, 100 mg All FDA black box warnings are at the end of this fact sheet. Please consult them before taking this medication. 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