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Zofran ® (ondansetron) is a medication that prevents nausea and vomiting by blocking serotonin receptors in the brain and gut involved in triggering the vomit reflex. Zofran is FDA-approved to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Generic Zofran (ondansetron) is often used off-label to manage nausea from other causes, such as illness … Compare prices and print coupons for Zofran and other medications at various pharmacies to save on your prescription costs. Zofran (ondansetron) is used to prevent nausea and vomiting caused by surgery or cancer medicines. Includes Zofran side effects, interactions and indications. Ondansetron comes as a tablet, a rapidly disintegrating (dissolving) tablet, and an oral solution (liquid) to take by mouth. The first dose of ondansetron is usually given before the start of chemotherapy, radiation, or surgery. Additional doses are taken depending on the type of treatment. 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