Imitrex Interactions There are 103 drugs known to interact with Imitrex (sumatriptan), along with 5 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 70 are major, and 33 are moderate. Imitrex is a brand-name drug used to treat migraine and cluster headache. Discover drug interactions in depth, when to avoid Imitrex, and more. Imitrex (sumatriptan) is used to treat migraine headaches, with or without aura, in adults. Includes Imitrex side effects, interactions and indications. Imitrex is a prescription drug used to treat migraine in adults. Learn about possible interactions with other drugs, alcohol, supplements, and more. Sumatriptan (Imitrex) interacts with MAO inhibitors like methylene blue and some SSRIs like Prozac. These interactions can increase the risk of serotonin syndrome. Sumatriptan is used for the management of acute migraine headaches with or without aura. It should not be used for more than 10 days a month or for chronic headaches. 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